[Breakdown of the blood-retino-vitreal barrier after photocoagulation]

The degree of breakdown of the blood-retino-vitreal barrier after Argon laser photocoagulation, and the possibility of preventing it by topical or oral administration of indomethacin, have been investigated in a study involving 58 eyes of 29 rabbits. Protein levels in the vitreous, as determined by densitometry, were four times higher in photocoagulated than in non-photocoagulated eyes (p less than 0.005). Neither topical nor oral administration of indomethacin was successful in preventing post-photocoagulation breakdown of the blood-retino-vitreal barrier at the dosages employed.