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31P magnetic resonance spectroscopy of chronic cerebral infarction in rats
1Neurochemistry Research Laboratory, Veterans Administration Medical Center, Martinez, California.
Abstract:
The chronological changes in the pattern of 31P magnetic resonance spectroscopy (MRS) associated with cerebral infarction were studied in rats. 31P MRS of chronic infarction (1 month after induction of infarction) clearly showed a pattern distinct from that of normal brain. In chronic infarction, the relative phosphomonoester (PME) level was found to be significantly higher and relative phosphocreatine (PCr) level significantly lower compared to normal brain. The intracellular pH and the relative inorganic phosphate (Pi) level did not show any significant differences. Histological examination indicated that the 31P MRS pattern of chronic infarction reflects gliosis.