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[Changes in laryngeal resistance and bronchial tonus]
S González-Barón1, M S Dawid-Milner, J P Lara
1Departamento de Fisiología, Facultad de Medicina, Málaga, España.
Revista Espanola De Fisiologia
|January 1, 1989
Summary
Larynx resistance, measured by subglottic pressure, was significantly altered by changes in bronchial tone. Bronchodilators like Fenoterol and Isoprenaline reversed bronchoconstriction, suggesting a reflexive glottis response to airway changes.
Area of Science:
- Respiratory Physiology
- Pulmonary Medicine
- Laryngeal Function
Context:
- Bronchial tone significantly influences airway resistance.
- Understanding the interplay between the larynx and bronchi is crucial for respiratory health.
- Previous research has not fully elucidated the reflexive mechanisms linking bronchial tone and laryngeal resistance.
Purpose:
- To investigate the relationship between changes in bronchial tone and larynx resistance in a feline model.
- To determine if bronchodilators and bronchoconstrictors affect laryngeal resistance.
- To explore the potential reflexive modulation of glottis contraction by bronchial tone.
Summary:
- Intravenous administration of Carbachol (bronchoconstrictor) increased subglottic pressure, indicating increased larynx resistance.
- Administration of Fenoterol and Isoprenaline (bronchodilators) decreased subglottic pressure, indicating decreased larynx resistance.
- Carbachol's effect on subglottic pressure was significantly blunted after bronchodilator administration.
- A strong positive correlation was observed between subglottic pressure and total lung resistance.
Impact:
- Findings suggest that glottis contraction is reflexively influenced by bronchial tone.
- This study provides insights into the neural control of the upper airway in response to lower airway stimuli.
- Potential implications for understanding and managing conditions involving airway hyperresponsiveness and laryngeal dysfunction.