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Updated: Apr 1, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
11.0K
[Bullous pemphigoid may also be seen in children]
Jens Otto Broby Madsen1, Anne Falensteen Lauritzen, Ulrikke Lei
1ulrikke.lei@regionh.dk.
Ugeskrift for Laeger
|September 30, 2015
Summary
Bullous pemphigoid, a skin condition, can affect children. Early diagnosis via biopsy and high-dose oral steroids offer a good prognosis with no relapse in a five-month-old boy.
Area of Science:
- Dermatology
- Pediatric Dermatology
- Autoimmune Blistering Diseases
Background:
- Bullous pemphigoid (BP) typically affects the elderly.
- Pediatric bullous pemphigoid (pBP) is increasingly recognized.
- Understanding pBP in infants is crucial for timely intervention.
Observation:
- A five-month-old male infant presented with widespread erythematous annular plaques.
- Vesicles and bullae were noted on the hands and feet.
- Clinical presentation mimicked other pediatric dermatoses.
Findings:
- Skin biopsy confirmed the diagnosis of bullous pemphigoid.
- High-dose oral corticosteroid therapy (1 mg/kg/day) was initiated.
- The patient showed a successful clinical response to treatment.
Implications:
- Early diagnosis and treatment of pBP in infants are essential.
- High-dose corticosteroids are effective in managing pediatric bullous pemphigoid.
- Long-term follow-up indicates a favorable prognosis with sustained remission.
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