[MODERN METHODS OF PROGNOSTICATION OF THE RECURRENCES OCCURRENCE AFTER SURGICAL TREATMENT OF THE MAMMARY GLAND BENIGN...

Area of Science:

• Oncology
• Genetics
• Surgical Treatment

Context:

• Benign tumors of the mammary gland (BTMG) require effective recurrence prediction strategies post-surgery.
• Existing recurrence prediction schemes for BTMG need further validation and refinement.

Purpose:

• To evaluate modern recurrence prediction schemes for benign tumors of the mammary gland (BTMG) after surgical treatment.
• To investigate the occurrence rate of BTMG recurrences over a five-year period.
• To explore potential genetic predispositions, specifically gene polymorphisms, associated with BTMG recurrence.

Summary:

• Retrospective analysis showed a 2.3% recurrence rate for BTMG over five years.
• Prospective observation revealed a 24.0% recurrence rate in patients with phylloid histologic forms of BTMG.
• BTMG recurrences were predominantly observed in women carrying mutant alleles for the GSR gene (rs8190924 polymorphism) and DKK4 gene (AA rs3763511 polymorphism).
• While not definitively confirmed as genetically determined, the odds ratio for these polymorphisms was 12.0 (95% CI: 0.8–14.9).

Impact:

• Identifies specific BTMG histologic types (phylloid) with higher recurrence rates.
• Highlights potential genetic markers (GSR and DKK4 polymorphisms) associated with BTMG recurrence.
• Provides data to inform future research on genetically influenced recurrence risk in BTMG.
• Contributes to improved patient stratification and personalized follow-up strategies for BTMG.