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[COMBINATION OF CELLS TECHNOLOGIES AND MINSIINVASIVE SURGERY IN THE TREATMENT OF CHRONIC GASTRIC ULCER]
Klinichna Khirurhiia
|March 8, 2016
Summary
Platelet-rich plasma (PRP) promotes healing of chronic gastric ulcers by stimulating cell growth and blood vessel formation. Combining PRP injections with standard therapy significantly improves ulcer healing compared to conservative treatment alone.
Area of Science:
- Regenerative Medicine
- Gastroenterology
- Wound Healing
Background:
- Chronic gastric ulcers pose a significant clinical challenge.
- Current treatments have limitations in promoting complete tissue regeneration.
- Stimulating local reparative processes is a promising therapeutic strategy.
Purpose of the Study:
- To analyze the efficacy of local regenerative stimulants in treating chronic gastric ulcers.
- To evaluate platelet-rich plasma (PRP) as a source of growth factors for ulcer healing.
- To compare the effectiveness of standard therapy with combined therapy including PRP.
Main Methods:
- Experimental analysis of autologous purified lipoaspirate and PRP.
- In vitro and in vivo studies on fibroblast activity and angiogenesis.
- Clinical trials involving endoscopic injection of PRP in chronic gastric ulcer patients.
Main Results:
- PRP demonstrated benefits as a donor of growth factors, stimulating fibroblast activity and new blood vessel formation.
- Enhanced oxygenation and cell proliferation in ulcer tissues were observed.
- Clinical studies showed superior ulcer healing with combined standard antiulcer therapy and PRP injections versus conservative therapy alone.
Conclusions:
- Platelet-rich plasma effectively stimulates local reparative processes in chronic gastric ulcers.
- PRP enhances tissue regeneration by promoting cell proliferation and vascularization.
- Combination therapy with PRP offers a significant advantage for chronic gastric ulcer treatment.
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