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Updated: Apr 1, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis.
Mark Lebwohl1, Bruce Strober, Alan Menter
1From the Icahn School of Medicine at Mount Sinai, New York (M.L., L.K.); University of Connecticut School of Medicine, Farmington (B.S.); Probity Medical Research (B.S., L.S., D.T.) and XLR8 Medical Research (D.T.), Windsor, ON, K Papp Medical Research (K.P.), Waterloo, ON, and Dalhousie University, Halifax, NS (R.G.L.) - all in Canada; Baylor University Medical Center, Dallas (A.M.); Northwestern University, Feinberg School of Medicine, Chicago (K.G.); Niepubliczny Zakład Opieki Zdrowotnej multiMedica, Wrocław (J.W.), and Lubelskie Centrum Diagnostyczne, Świdnik (T.B.) - both in Poland; Hospital de la Santa Creu i Sant Pau, Barcelona (L.P.); Veracity Clinical Research, Woolloongabba, QLD, Australia (L.S.); Florida Academic Dermatology Center, Miami (F.K.); University of Colorado, Denver (A.W.A.); Medizinische Universität Wien, Vienna, Austria (G.S.); Massachusetts General Hospital and Harvard Medical School, Boston (A.B.K.); Sorbonne Paris Cité Université Paris Diderot, Assistance Publique-Hôpitaux de Paris Hôpital Saint Louis, Paris (H.B.), Paul Sabatier University, Toulouse (C.P.), and University Hospital of Nice, Nice (J.-P.L.) - all in France; Kaiser Permanente Los Angeles Medical Center, Los Angeles (J.J.W.), Bakersfield Dermatology and Skin Cancer Medical Group, Bakersfield (J.C.), University of California, San Francisco, San Francisco (J.K.), and Amgen, Thousand Oaks (G.A., J.L., W.S., C.E.M., Y.S., N.E., P.K., B.K., A.N.) - all in California.; University of Texas Health Science Center, Houston (S.T.); DermResearch, Louisville, KY (L.K.); University of Rome Tor Vergata, Rome (S.C.); University of Utah Medical Center, Salt Lake City (K.C.D.); and the Psoriasis Treatment Center of Central New Jersey, East Windsor (J.B.).
Brodalumab significantly improved moderate-to-severe psoriasis compared to placebo and ustekinumab, demonstrating high efficacy in achieving clear or almost clear skin. Further studies confirmed its clinical benefits in psoriasis patients.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Early studies indicated brodalumab's potential for treating psoriasis.
- Brodalumab is a monoclonal antibody targeting the interleukin-17 receptor A.
Purpose of the Study:
- To evaluate the efficacy and safety of brodalumab in patients with moderate-to-severe psoriasis.
- To compare brodalumab's effectiveness against ustekinumab and placebo.
Main Methods:
- Two Phase 3 randomized controlled trials (AMAGINE-2 and AMAGINE-3) were conducted.
- Patients received brodalumab, ustekinumab, or placebo, with subsequent dose adjustments for brodalumab.
- Primary endpoints included PASI 75, sPGA scores of 0 or 1, and PASI 100 at week 12.
Main Results:
- Brodalumab (210 mg and 140 mg) demonstrated significantly higher PASI 75 and sPGA 0/1 response rates versus placebo at week 12.
- The 210 mg dose of brodalumab showed significantly higher PASI 100 rates compared to ustekinumab at week 12.
- Adverse events included increased rates of neutropenia and candida infections with brodalumab; serious infections occurred at low rates.
Conclusions:
- Brodalumab treatment led to substantial clinical improvements in patients with moderate-to-severe psoriasis.
- The study confirms brodalumab's efficacy as a treatment option for psoriasis.
- ClinicalTrials.gov identifiers: NCT01708603 and NCT01708629.
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