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Updated: Apr 1, 2026

Purification of High Yield Extracellular Vesicle Preparations Away from Virus
Published on: September 12, 2019
Intercellular Transmission of Viral Populations with Vesicles
Nihal Altan-Bonnet1, Ying-Han Chen2
1Laboratory of Host-Pathogen Dynamics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA nihal.altan-bonnet@nih.gov.
Abstract:
A common paradigm holds that during cell-to-cell transmission, viruses behave as lone soldiers. Recently, we discovered not only that enteroviruses are transmitted via vesicles as populations of viral particles but also that this type of transmission enhances their infection efficiency (Y. H. Chen et al., Cell 160: 619-630, 2015). This mechanism could be advantageous for the overall fitness of the viral population, promoting genetic interplay by enabling viral quasispecies to collectively infect a susceptible host cell. Here, we discuss these findings in the context of viral pathogenesis and also propose that this novel type of vesicular transmission is widespread among different virus families and includes populations of both viral particles and naked viral genomes.
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