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The Mosaic of Rottlerin
Kenneth K C Hong1, Graham E Ball1, David StC Black1
1School of Chemistry, The University of New South Wales , Sydney, New South Wales 2052, Australia.
Abstract:
The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C δ (PKCδ) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl3 as a catalyst.
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