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Binding sites for gonadotropins in human postmenopausal ovaries
1Department of Obstetrics and Gynecology, Wakayama Medical College, Japan.
Obstetrics and Gynecology
|February 1, 1989
Summary
Postmenopausal ovaries have binding sites for pituitary gonadotropins like luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These findings suggest a role for the postmenopausal ovary in steroidogenesis.
Area of Science:
- Endocrinology
- Reproductive Biology
- Gynecologic Oncology
Background:
- The role of the postmenopausal ovary in hormone production is not fully understood.
- Investigating the presence and function of gonadotropin receptors in postmenopausal ovarian tissue is crucial.
Purpose of the Study:
- To analyze the binding of human luteinizing hormone (LH) and human follicle-stimulating hormone (FSH) to postmenopausal ovarian tissue.
- To investigate the localization of gonadotropin binding sites and steroidogenic activity in the postmenopausal ovary.
Main Methods:
- Analysis of human LH and FSH binding to postmenopausal ovarian tissue from 21 patients.
- Immunohistochemical and histochemical detection of endogenous estrogen and 3 beta-hydroxysteroid dehydrogenase activity.
- Electron microscopy to assess cellular function.
Main Results:
- Specific binding sites for FSH and LH were identified in postmenopausal ovarian tissue.
- These binding sites were localized to the cortical stroma cells.
- Cortical stroma cells showed evidence of endogenous estrogen and steroidogenic activity, confirmed by electron microscopy.
Conclusions:
- Postmenopausal ovaries possess specific binding sites for pituitary gonadotropins.
- The cortical stroma of the postmenopausal ovary plays a role in ovarian steroidogenesis.