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Updated: Apr 1, 2026

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
Published on: May 17, 2019
[Update on extracorporeal photopheresis]
1Universitätsklinik für Dermatologie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich. ulrike.just@meduniwien.ac.at.
Extracorporeal photopheresis (ECP) is a safe and effective treatment that uses UVA light to treat nucleated cells. This therapy is increasingly used for cutaneous T cell lymphoma and other immune-mediated diseases.
Area of Science:
- Immunology
- Photomedicine
Context:
- Extracorporeal photopheresis (ECP) is a therapeutic procedure combining leukapheresis and photochemotherapy.
- It involves extracorporeal irradiation of nucleated cells, primarily lymphocytes and monocytes, with UVA light after photosensitization.
Purpose:
- To summarize the efficacy and expanding indications of ECP.
- To highlight its effectiveness in treating cutaneous T cell lymphoma and other immune-mediated conditions.
Summary:
- ECP is derived from PUVA and effectively treats lymphocyte-mediated diseases.
- The procedure has a favorable side effect profile.
- Its application has broadened to various autoimmune and inflammatory conditions characterized by autoreactive T cell proliferation.
Impact:
- ECP offers a valuable therapeutic option with minimal side effects.
- The expanding use of ECP signifies its growing importance in managing complex immune disorders.
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