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Establishment and validation of a 384-well antibacterial assay amenable for high-throughput screening and combination
Arti Mishra1, Svetlana V Dobritsa2, Marie-Laure Crouch3
1Biology and Pharmacology, Albany Molecular Research, Inc., The Galen, #05-01, 61 Science Park Road, 117525, Singapore.
Journal of Microbiological Methods
|October 4, 2015
Abstract:
A 384-well-based antibacterial assay amenable for high-throughput screening and combination testing is described. The assay uses 100-500nL of test compounds and tolerates up to 2.5% dimethyl sulfoxide concentrations. It can be used for screening compound libraries and testing combinatory/synergistic/antagonistic effects of antibiotics, small molecules, and natural product extracts.
