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Updated: Aug 13, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Assessment of disease progress in psoriasis
R Marks1, S P Barton, D Shuttleworth
1Department of Medicine (Dermatology), University of Wales College of Medicine, Heath Park, Cardiff.
Archives of Dermatology
|February 1, 1989
Summary
Accurate psoriasis assessment is crucial for therapy evaluation. This study reveals significant variability among clinicians in measuring psoriasis severity, highlighting the need for objective assessment methods.
Area of Science:
- Dermatology
- Clinical Trials
- Medical Imaging
Background:
- Accurate measurement of psoriasis signs is vital for assessing treatment efficacy.
- Current clinical assessment methods for psoriasis exhibit significant variability and observer error.
- Objective assessment methods may offer advantages over subjective clinical evaluations.
Purpose of the Study:
- To review and analyze psoriasis assessment techniques used in clinical trials.
- To evaluate the reproducibility of subjective clinician assessments of psoriasis severity.
- To compare subjective clinician assessments with objective, computer-assisted measurements.
Main Methods:
- Review of assessment methods in 30 chronic plaque psoriasis clinical trials (1985-1986).
- Standardized photography of 10 psoriasis patients.
- Subjective assessment of lesion area by four clinicians from photographs.
- Objective assessment of lesion area using computer-assisted planimetry.
Main Results:
- Wide variation in scoring methods and regional assessment across reviewed trials.
- Clinicians showed significant differences in ranking psoriasis lesion area from photographs.
- Subjective assessments, while not random, varied in accuracy compared to objective measurements.
- Experienced clinicians demonstrated considerable variability in assessing psoriasis severity.
Conclusions:
- Existing clinical assessment methods for psoriasis severity lack consistency.
- Subjective evaluation of psoriasis area by clinicians is prone to significant inter-observer variability.
- There is a clear need for the development and implementation of more objective measures for psoriasis severity assessment.
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