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Abdominal aortic aneurysms and diabetes mellitus
Kalliopi Pafili1, Ioanna Gouni-Berthold2, Nikolaos Papanas1
1Diabetes Clinic, Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Journal of Diabetes and Its Complications
|October 7, 2015
Summary
Diabetes mellitus (DM) shows a negative association with abdominal aortic aneurysm (AAA) formation. Potential mechanisms involve altered matrix formation and reduced inflammation, though further research on medications is needed.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Vascular Biology
Background:
- Risk profiles for coronary artery disease and abdominal aortic aneurysms (AAAs) differ.
- Diabetes mellitus (DM) appears to be negatively associated with AAA formation, a relationship not fully understood.
Purpose of the Study:
- To explore the potential mechanisms behind the negative association between DM and AAA formation.
- To review the controversial effects of pharmacological agents used in DM treatment on AAA development.
Main Methods:
- Literature review of studies investigating the relationship between DM and AAA.
- Analysis of proposed biological mechanisms, including advanced glycation end products and matrix metalloproteinases.
- Examination of research on pharmacological agents and their impact on AAA formation.
Main Results:
- DM may reduce AAA risk through increased arterial matrix formation, suppressed plasmin, reduced matrix metalloproteinases (MMP)-2 and 9, and diminished aortic inflammation.
- Pharmacological agents like statins, ACE inhibitors, ARBs, fenofibrate, and some hypoglycemic agents may offer modest protection against AAAs.
Conclusions:
- The inverse relationship between DM and AAAs is supported by potential mechanistic pathways involving matrix regulation and inflammation.
- Certain medications used for DM management might confer a protective effect on AAA formation, warranting further investigation.
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