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Related Experiment Video

Updated: Apr 1, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Clear Cell Sarcoma Of Metatarsus.

Luana Licata¹, Domenico Fenga², Giuseppe Speciale¹

¹Department of Human Pathology, Section of Pathological Anatomy, Azienda Ospedaliera Universitaria Policlinico G. Martino, Messina, Italy

|October 8, 2015

Summary

This study details a rare case of clear cell sarcoma on the foot's metatarsus in a 42-year-old male. Treatment involved trans-tibial amputation due to the aggressive nature of this rare sarcoma.

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Area of Science:

Orthopedic Oncology
Skeletal Pathology

Background:

Clear cell sarcoma is an exceptionally rare soft tissue neoplasm.
Literature reports on clear cell sarcoma, particularly in the foot's metatarsus, are scarce.

Observation:

A 42-year-old male presented with a nodular, ulcerated mass on the dorsal aspect of his left foot.
Radiographic imaging revealed a lesion impacting the third metatarsus.
Histopathological and immunohistochemical analyses confirmed a clear cell sarcoma profile.

Findings:

The tumor exhibited aggressive characteristics, necessitating extensive surgical intervention.
Magnetic Resonance Imaging (MRI) and bone scan indicated forefoot and ankle involvement.
A trans-tibial amputation was performed to ensure optimal patient functionality.

Implications:

This case highlights the importance of considering rare sarcomas in foot pathologies.
The study emphasizes the multimodal diagnostic approach for clear cell sarcoma.
Early detection and appropriate surgical management are crucial for improving outcomes in rare bone tumors.