Related Experiment Video
Updated: Apr 1, 2026
07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
13.4K
ENDOGENOUS ENDOPHTHALMITIS CAUSED BY BRUCELLA MELITENSIS.
1Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Retinal Cases & Brief Reports
|October 8, 2015
Summary
Brucella melitensis endophthalmitis is rare but treatable. Prompt diagnosis and management, including vitrectomy and antibiotics, successfully restored vision in a young patient.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Brucella is an intracellular gram-negative pathogen and facultative parasite.
- Endogenous endophthalmitis caused by Brucella melitensis is exceptionally rare.
- This case highlights an unusual presentation of B. melitensis endophthalmitis.
Observation:
- An 18-year-old male presented with prolonged fever and subsequent vision loss in his left eye.
- Ocular examination revealed severe anterior chamber reaction and vitritis.
- Initial systemic investigations for fever of unknown origin were negative.
Findings:
- Diagnostic and therapeutic vitrectomy identified Brucella melitensis as the causative agent.
- The patient's vision improved to 20/150 following vitrectomy and antibiotic treatment.
- Post-treatment examination showed a quiet eye with resolved inflammation and some macular changes.
Implications:
- Early suspicion and prompt intervention are crucial for managing B. melitensis endophthalmitis.
- Vitrectomy combined with targeted antibiotic therapy can successfully salvage vision in these rare cases.
- This case underscores the importance of considering Brucella in the differential diagnosis of endophthalmitis, especially in endemic areas.
Related Concept Videos
01:22Microbiome of the Eye
37
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
37
01:25Glaucoma: Overview
1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
01:25Endocarditis I: Introduction
769
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
769