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Applications of Natural Polymeric Materials in Solid Oral Modified-Release Dosage Forms
Liang Li, Xin Zhang, Xiangqin Gu
1School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016, Shenyang, China. maoshirui@syphu.edu.cn.
Current Pharmaceutical Design
|October 9, 2015
Summary
Natural polymers like chitosan and alginate are effective for modified-release drug delivery systems. Further research into their in vivo behavior and quality control is needed for wider commercial use.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Solid oral modified-release dosage forms offer advantages over immediate-release formulations.
- Natural polymers are attractive drug carriers due to safety, biocompatibility, and biodegradability.
Purpose of the Study:
- To review the applications of natural polymers in solid oral modified-release dosage forms.
- To highlight the potential and challenges of using natural polymers in drug delivery.
Main Methods:
- Literature review of natural polymers (chitosan, alginate, pectin, guar gum, xanthan gum) in modified-release dosage forms.
- Analysis of different dosage form types (matrix tablets, pellets, beads) and specialized systems (gastroretentive, colon-specific).
Main Results:
- Natural polymers are widely used in various solid oral modified-release dosage forms.
- Chemical modification and polymer combinations enhance performance.
- Gastroretentive and colon drug delivery systems show significant application.
Conclusions:
- Natural and modified natural polymers show promise for solid oral modified-release drug delivery.
- Limited commercial products exist, necessitating further in vivo studies, strict quality control, and understanding of formulation parameters.
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