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Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
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Antiasthma Drugs: Muscarinic Receptor Antagonists01:20

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Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
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Updated: Apr 1, 2026

Basophil Activation Test for Allergy Diagnosis
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Montelukast: Chronic Urticaria.

Joyce A Generali1, Dennis J Cada2

  • 1Editor-in-Chief, Hospital Pharmacy , and Clinical Professor, Emeritus, Department of Pharmacy Practice, University of Kansas, School of Pharmacy , Kansas City/Lawrence, Kansas ,

Hospital Pharmacy
|October 9, 2015
PubMed
Summary
This summary is machine-generated.

This resource guides healthcare professionals in evaluating unapproved drug uses. It helps identify literature on off-label drug applications for rational patient care decisions.

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Area of Science:

  • Pharmacy
  • Clinical Pharmacology
  • Drug Utilization

Background:

  • Off-label drug use is common in clinical practice.
  • Information on unapproved drug uses is often fragmented.
  • Healthcare professionals need reliable resources to assess off-label drug safety and efficacy.

Purpose of the Study:

  • To introduce a practitioner-oriented resource for off-label drug information.
  • To enable clinicians to identify and evaluate published studies on unapproved drug uses.
  • To support rational patient care decisions regarding off-label drug applications.

Main Methods:

  • Extraction of information from the publication 'Off-Label Drug Facts'.
  • Focus on literature guiding the identification of studies on specific off-label drug uses.
  • Provision of references for further comprehensive literature review.

Main Results:

  • A guide is available for healthcare professionals to access information on off-label drug uses.
  • The resource facilitates the assessment of the rationality of specific off-label drug applications.
  • Literature references are provided for in-depth understanding.

Conclusions:

  • 'Off-Label Drug Facts' serves as a valuable tool for clinicians.
  • It supports evidence-based decision-making for unapproved drug uses.
  • The resource promotes rational and informed patient care.