Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy of dual-modality ablation for symptomatic cystic thyroid nodules.

Gland surgery·2026

Same author

Rare But Risky: Clinical Impacts of Pneumothorax After Thyroidectomy and Parathyroidectomy.

The Laryngoscope·2026

Same author

Beyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto's thyroiditis.

Gland surgery·2026

Same author

Impact of cervical thymectomy on multiple endocrine neoplasia type 1 patients undergoing parathyroidectomy for primary hyperparathyroidism.

Surgery·2026

Same author

[Corrigendum] Tumor necrosis factor‑α triggers opposing signals in head and neck squamous cell carcinoma and induces apoptosis via mitochondrial‑ and non‑mitochondrial‑dependent pathways.

International journal of oncology·2026

Same author

Epigenetics of Genes Displaying High and Preferential Expression in Myoblasts.

Epigenomes·2026

Same journal

Evaluating a Novel Cell-Free Preservation Solution for Human Cardiomyocyte Protection: A Proof-of-Concept Study.

BioMed research international·2026

Same journal

Clinical Efficacy of Chinese Medicine in Treating Adult Henoch-Schönlein Purpura: A Meta-Analysis.

BioMed research international·2026

Same journal

RETRACTION: Rehabilitation Training and Resveratrol Improve the Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through the Sirt1 Signaling Pathway.

BioMed research international·2026

Same journal

The Oncogenic and Tumor-Suppressive Roles of SNHG18: A Double-Edged Long Noncoding RNA in Cancer.

BioMed research international·2026

Same journal

Evaluation of LncRNA NEAT1 and MEG3 Expression Levels in Hospitalized COVID-19 Patients.

BioMed research international·2026

Same journal

Perceived Self-Efficacy and Its Determinants for Noncommunicable Disease Prevention Among Adults in Southern Ethiopia: A Community-Based Cross-Sectional Study.

BioMed research international·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 1, 2026

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

BRAF Testing in Multifocal Papillary Thyroid Carcinoma.

Hillary Z Kimbrell¹, Andrew B Sholl¹, Swarnamala Ratnayaka¹

¹Department of Pathology and Laboratory Medicine, Tulane University, 1430 Tulane Avenue SL-79, New Orleans, LA 70112, USA.

Biomed Research International

|October 9, 2015

Summary

This summary is machine-generated.

In multifocal papillary thyroid carcinoma (PTC), the BRAF V600E mutation may be present in smaller tumors even if the largest tumor tests negative. Testing multiple tumors is recommended for accurate BRAF mutation status in PTC.

More Related Videos

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

Related Experiment Videos

Last Updated: Apr 1, 2026

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

Area of Science:

Oncology
Molecular Diagnostics
Genetics

Background:

Papillary thyroid carcinoma (PTC) with BRAF V600E mutation indicates a poor prognosis.
Multifocal PTC presents a challenge as testing guidelines for BRAF mutations are lacking.

Purpose of the Study:

To investigate the concordance of BRAF V600E mutation status in multifocal papillary thyroid carcinoma (PTC).
To determine if testing only the largest tumor is sufficient for BRAF mutation detection in multifocal PTC.

Main Methods:

Analyzed 57 PTC tumors from 27 patients using a commercial real-time PCR assay.
Collected data on tumor histology, patient demographics, and clinical outcomes.

Main Results:

BRAF V600E was the only mutation detected.
Mutation status was concordant in 63% of patients between the largest and second-largest tumors.
Discordant results were observed in 37% of patients, with 22% having a BRAF-negative largest tumor and a BRAF-positive smaller tumor.

Conclusions:

BRAF V600E-positive tumors can be missed if only the largest tumor in multifocal PTC is tested.
Consider molecular testing of multiple tumors in multifocal PTC.
Further research is needed to clarify the clinical significance of BRAF mutations in smaller PTC tumors.