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Relationship Between Parathormone and Obesity-Linked Disorders
Sule Temizkan1, Sevin Demir2, Kadriye Aydin1
11 Department of Endocrinology and Metabolic Diseases, Kartal Dr. Lutfi Kirdar Training and Research Hospital , Istanbul, Turkey .
Metabolic Syndrome and Related Disorders
|October 10, 2015
Summary
High parathormone (PTH) levels do not appear to cause metabolic issues in obese individuals. However, lower levels of 25-hydroxyvitamin D (25(OH)D) were linked to reduced high-density lipoprotein cholesterol (HDL-C).
Area of Science:
- Endocrinology
- Metabolic Health
- Nutritional Science
Background:
- Obesity is linked to various metabolic complications.
- The role of parathormone (PTH) in obesity-related metabolic dysfunction requires further investigation.
Purpose of the Study:
- To determine if elevated parathormone (PTH) levels contribute to metabolic complications in obese patients.
- To explore the relationship between PTH, 25-hydroxyvitamin D (25(OH)D), and metabolic syndrome components in obesity.
Main Methods:
- A cohort of 400 obese adults (aged 18-65) was analyzed.
- Data collected included anthropometric measurements, bioelectrical impedance analysis, blood tests, and oral glucose tolerance tests.
- Subjects were stratified into quartiles based on PTH levels for comparative analysis.
Main Results:
- No significant differences in blood pressure, fasting glucose, insulin resistance, or triglyceride levels were observed across PTH quartiles.
- Parathormone (PTH) and 25-hydroxyvitamin D (25(OH)D) levels were not associated with an increased likelihood of metabolic syndrome in obese subjects.
- Lower 25-hydroxyvitamin D (25(OH)D) levels showed a significant correlation with a higher likelihood of low high-density lipoprotein cholesterol (HDL-C).
Conclusions:
- Parathormone (PTH) does not appear to be a contributing factor to the metabolic components of obesity.
- A positive correlation exists between 25-hydroxyvitamin D (25(OH)D) and high-density lipoprotein cholesterol (HDL-C) levels in obese individuals.
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