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10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
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Bladder stones after bladder augmentation are not what they seem.
Konrad M Szymanski1, Rosalia Misseri1, Benjamin Whittam1
1Division of Pediatric Urology, Riley Hospital for Children at IU Health, 705 Riley Hospital Dr., Suite 4230, Indianapolis, IN 46202, USA.
Journal of Pediatric Urology
|October 13, 2015
Summary
Bladder augmentation patients frequently develop non-infectious bladder and renal stones. Recurrence patterns suggest a possible metabolic component, as clinical factors don't predict stone composition.
Area of Science:
- Urology
- Nephrology
- Biochemistry
Background:
- Bladder and renal calculi post-bladder augmentation are often presumed infectious.
- Limited data exists on the precise stone composition in these patients.
Purpose of the Study:
- To determine bladder stone composition after augmentation.
- To analyze renal stone composition in patients with subsequent nephrolithiasis.
- To identify potential risk factors for infectious stone formation.
Main Methods:
- Retrospective review of patients with bladder stones post-augmentation (1981-2012).
- Analysis of stone composition, classifying stones as infectious (struvite, carbonate apatite, ammonium acid urate) or non-infectious.
- Univariate and bivariate analysis of clinical variables for association with infectious stone composition.
Main Results:
- 30.8% of bladder stones and 60.0% of renal stones were non-infectious.
- Recurrence with non-infectious stones occurred more frequently after initial non-infectious stones (84.6%).
- No clinical variables were significantly associated with infectious stone composition.
Conclusions:
- A significant proportion of bladder and renal stones post-bladder augmentation are non-infectious.
- Stone recurrence does not consistently follow an infectious pattern.
- The findings suggest a potential metabolic etiology for stone formation, as clinical risk factors were not identified.
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