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Updated: Apr 1, 2026
Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy
Published on: September 29, 2017
[Flow mediated vasodilation in overweight children]
Diego Rodríguez1, Mauricio Coll2, Rafael Guerrero2
1Departamento de Pediatría, Universidad Nacional de Colombia, Bogotá, Colombia; Hospital de la Misericordia, Bogotá, Colombia; Clínica San Luis, Bucaramanga, Colombia.
Introduction:
Present knowledge suggests that cardiovascular disease originates and progresses from childhood and adolescence. Endothelial dysfunction is an early and crucial event in atherosclerosis.
Patients And Method:
Prospective study that compares Flow Mediated Vasodilation (FMV) in children with overweight (OWC) and normal weight children. An ultrasound transducer a standard method were used to measure FMD.
Results:
The study included 82 children, of whom 49 were cases (OWC) and 33 controls. FMV values ranged from -6 to 56% (x=11.1%) in OW, and from 0 to 29.6% (x=16.6%) in control children (P<.005). Paradoxical vasoconstriction was found in 34.7% in OWC as compared to nil in controls (P<.005). A significant association was found between vasoconstriction and central obesity and hypertension.
Conclusion:
The results of this study show that FMV is lower in obese compared to normal children; thus they are more likely to have endothelial dysfunction.
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