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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
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PET imaging of the autonomic myocardial function: methods and interpretation
Walter Noordzij1, Riemer H J A Slart1
1Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, 9700 RB Groningen, The Netherlands.
Clinical and Translational Imaging
|October 13, 2015
Summary
Positron emission tomography (PET) offers advanced cardiac imaging for myocardial innervation. While not yet widespread clinically, PET
Area of Science:
- Nuclear cardiology
- Molecular imaging
- Neuroscience
Background:
- Cardiac positron emission tomography (PET) is primarily used for myocardial perfusion and viability.
- Noninvasive imaging of myocardial innervation via PET presents a valuable, yet underutilized, diagnostic tool in cardiac care.
- Current clinical adoption of PET for autonomic heart imaging is limited despite its technical merits.
Approach:
- Development of novel methods and PET ligands to assess presynaptic and postsynaptic function within the cardiac neuronal system.
- Quantitative and qualitative analysis of acquired PET data.
- Utilizing adjusted generic software tools for the interpretation and quantification of PET innervation scans, as dedicated commercial software is currently unavailable.
Key Points:
- PET ligands enable detailed measurement of cardiac neuronal system function.
- Quantitative analysis of PET data is crucial for accurate interpretation.
- Specialized software for cardiac PET innervation analysis is lacking, necessitating the use of adaptable generic tools.
Conclusions:
- Cardiac PET imaging for myocardial innervation holds significant potential for clinical application.
- Technical advantages and imaging agent properties support PET's expanded role in cardiology.
- Further development and accessibility of dedicated analysis tools could enhance the clinical utility of cardiac PET innervation imaging.
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