Destruction and Construction: Application of Dearomatization Strategy in Aromatic Carbon-Nitrogen Bond
Shuo-En Wang1, Linfei Wang1, Qiuqin He1
1Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 (China).
Abstract:
The formation of carbon-carbon bonds through the functionalization of aromatic carbon-nitrogen bonds is a highly attractive synthetic strategy in the synthesis of aromatic molecules. In this paper, we report a novel aromatic carbon-nitrogen bond functionalization reaction by using a simple dearomatization strategy. Through this process para-substituted anilines serve as a potential aryl source in the construction of a range of functionalized aromatic molecules, such as quaternary carbon centers, α-keto esters, and aldehydes.
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