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Updated: Apr 25, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis of furoquinolines from 2-alkenylanilines via anodic dearomatization and cascade cyclization
Xin Feng1,2, Renhua Fan1, Qiuqin He1
1Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China. qqhe@fudan.edu.cn.
Abstract:
Herein, we report an anodic dearomatization reaction followed by a one-pot nucleophilic cycloaddition/Bischler-Napieralski reaction of 2-alkenylanilines for the construction of structurally diverse dihydrofuro[2,3-g]quinolinones. These compounds represent an understudied subclass of furoquinoline scaffolds. This metal-free protocol features high atom economy and good functional group tolerance, providing a practical route to dihydrofuro[2,3-g]quinolinones. Notably, these products can be readily oxidized to furo[2,3-g]quinolines, which hold potential for the preparation of bioactive compounds.
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