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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Predictive Immune Modeling of Solid Tumors
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The Immunotherapy Roadmap.

James C Yang1

  • 1Surgery Branch, National Cancer Institute, Bethesda, Maryland. jamesyang@mail.nih.gov.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|October 14, 2015
PubMed
Summary
This summary is machine-generated.

New immunotherapies are emerging, requiring combination treatments for most cancers. Personalized tumor analysis will guide these effective cancer therapy combinations.

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Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Genomics

Background:

  • The development of novel immunotherapeutic agents is rapidly advancing.
  • Effective treatment of most human cancers will likely necessitate combination therapies.

Purpose of the Study:

  • To highlight the critical role of combination immunotherapies in cancer treatment.
  • To emphasize the importance of personalized tumor analysis in guiding treatment strategies.

Main Methods:

  • Review of current advancements in immunotherapy.
  • Analysis of the potential of personalized tumor profiling.

Main Results:

  • Combination immunotherapies are essential for overcoming cancer resistance.
  • Personalized patient tumor analysis provides a roadmap for selecting optimal treatment combinations.

Conclusions:

  • The integration of personalized tumor analysis with combination immunotherapy represents the future of cancer care.
  • Tailoring treatment based on individual tumor characteristics is key to improving patient outcomes.