Effects of RHAMM/HMMR-Selective Peptides on Survival of Breast Cancer Cells
N P Akent'eva1, S S Shushanov2, A I Kotel'nikov3
1Institute of Chemical Physics Problems, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia. na_aken@icp.ac.ru.
Bulletin of Experimental Biology and Medicine
|October 14, 2015
Abstract:
RHAMM-selective peptides in a concentration of 10 μg/ml (2×10(-7) M) inhibited the growth of MDA-MB-231 breast cancer cells over 48 h. Treatment of cancer cells with RHAMM-selective peptides induced apoptosis and necrosis and increased caspase-3 activity (by 30%).
Keywords:
RHAMM-selective peptidesRHAMM/HMMR (hyaluronan-mediated motility receptor)apoptosisbreast cancernecrosis

