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Related Experiment Videos

Proficiency testing in a medical-needs context.

J A Lott1, N R Manning, M K Kyler

  • 1Department of Pathology, Ohio State University, Columbus 43210.

Clinical Chemistry
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

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Proficiency testing in clinical chemistry labs needs medical-needs criteria, not strict statistics, for accurate quality assessment. Tailored criteria improve lab result reliability for screening and patient monitoring.

Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Quality Assurance

Background:

  • Proficiency testing is crucial for clinical laboratory quality assurance.
  • Current strict statistical evaluations of laboratory values are often inappropriate.
  • Laboratory result quality is influenced by technology and testing goals.

Purpose of the Study:

  • To advocate for medical-needs criteria over strict statistical evaluations in proficiency testing.
  • To propose tailored proficiency testing limits based on different medical needs.
  • To evaluate total error, including bias and imprecision, for common clinical chemistry tests.

Main Methods:

  • Defined three medical-needs criteria: population screening, short-term monitoring, and long-term monitoring.

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  • Established explicit proficiency-testing limits for nine common clinical chemistry tests.
  • Considered total error (bias and imprecision) in limit setting.

    • Main Results:

    • Demonstrated that medical-needs criteria are more appropriate for proficiency testing than strict statistical evaluations.
    • Provided specific proficiency-testing limits for common analytes across different medical-needs criteria.
    • Found that broader limits are acceptable for enzyme tests in population screening.

    Conclusions:

    • Medical-needs criteria should guide proficiency testing for clinical laboratories.
    • Tailored proficiency testing limits enhance the reliability of laboratory results.
    • Continuous improvement in analytical technology has reduced imprecision in clinical chemistry testing.