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Biologic Therapy in Immune Mediated Inflammatory Disease: Basic Science and Clinical Concepts
E Molinelli1, A Campanati, G Ganzetti
1Dermatology Unit Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy. molinelli.elisa@gmail.com.
Current Drug Safety
|October 15, 2015
Summary
Biological therapies, including tumor necrosis factor-α antagonists and interleukin-12/23 inhibitors, have transformed immune-mediated inflammatory disorder treatment. This review details their efficacy, safety, and administration for conditions like IBD, arthritis, and psoriasis.
Area of Science:
- Immunology
- Pharmacology
- Gastroenterology
Background:
- Biological therapies have revolutionized immune-mediated inflammatory disorder management.
- Key biologic classes include TNFα antagonists and IL-12/23 inhibitors.
- These therapies significantly impact patient quality of life and healthcare economics.
Purpose of the Study:
- To review the biology and immunological effects of TNFα, IL-12, and IL-23.
- To detail the efficacy and safety of current biologic therapies.
- To discuss administration, pharmacodynamics, and side effects of biologics.
Main Methods:
- Literature review of biological therapies for immune-mediated inflammatory disorders.
- Summary of TNFα, IL-12, and IL-23 signaling pathways.
- Detailed analysis of licensed biologics, including dosing and administration.
Main Results:
- Biologics targeting TNFα and IL-12/23 pathways show remarkable efficacy.
- Established therapeutic strategies for inflammatory autoimmune diseases.
- Extensive safety profiles are monitored for these advanced treatments.
Conclusions:
- Biological therapies represent a cornerstone in managing immune-mediated inflammatory disorders.
- Understanding biologic mechanisms, administration, and safety is crucial.
- These treatments offer significant benefits for patients with IBD, arthritis, and psoriasis.
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