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Related Concept Videos

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Related Experiment Video

Updated: Mar 31, 2026

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
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Necrotizing Enterocolitis in the Full-Term Infant.

Alison Chu, Harvey K Chiu

    Pediatric Annals
    |October 17, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Necrotizing enterocolitis in full-term infants is rare but can signal underlying issues. This case highlights pan-hypopituitarism as a cause of persistent hypoglycemia and necrotizing enterocolitis in a full-term infant.

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    Area of Science:

    • Pediatrics
    • Neonatology
    • Endocrinology

    Background:

    • Necrotizing enterocolitis (NEC) is uncommon in full-term infants.
    • NEC in term infants is often linked to perinatal asphyxia, sepsis, or congenital heart defects.
    • Endocrinopathies are a less common but potential association with NEC.

    Observation:

    • A full-term infant presented with necrotizing enterocolitis and persistent hypoglycemia.
    • Diagnostic evaluation for persistent hypoglycemia identified pan-hypopituitarism.
    • Magnetic resonance imaging (MRI) confirmed the diagnosis of pan-hypopituitarism.

    Findings:

    • Pan-hypopituitarism can manifest as persistent hypoglycemia in neonates.
    • NEC may be an presenting sign of underlying pan-hypopituitarism in full-term infants.
    • Early diagnosis and treatment of pan-hypopituitarism are crucial.

    Implications:

    • Timely diagnosis of pan-hypopituitarism is essential for affected infants.
    • Early hormone replacement therapy can mitigate long-term complications of pan-hypopituitarism.
    • This case underscores the importance of considering endocrine disorders in term infants with NEC and hypoglycemia.