Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Accessory Structures of the Skin: Sebaceous Glands

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Singlár et al. Revealing the Specific Contributions of Mitochondrial CB<sub>1</sub> Receptors to the Overall Function of Skeletal Muscle in Mice. <i>Cells</i> 2025, <i>14</i>, 1517.

Cells·2026

Same author

DHCR24 Deficiency Drives Age-Related Meibomian Gland Dysfunction by Regulating Lipid Metabolic Imbalance and Cytosolic mtDNA-Induced cGAS-STING Activation.

International journal of biological sciences·2026

Same author

ChatGPT, Gemini, and Claude in clinical and dermoscopic image analysis of basal cell carcinoma and its common mimickers: A comparative performance analysis.

JID innovations : skin science from molecules to population health·2026

Same author

Lactobacillus-derived extracellular vesicles provide multi-target acne treatment by enriched proteins and skin microbiota protection.

Journal of nanobiotechnology·2026

Same author

Exposome involvement in the development of acne vulgaris.

Frontiers in immunology·2026

Same author

Hidradenitis suppurativa: Intentional efforts to unravel precise mechanisms.

The Journal of investigative dermatology·2026

Search research articles

Related Experiment Video

Updated: Mar 31, 2026

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

Sebocytes differentially express and secrete adipokines.

Dóra Kovács^1,2, Marianna Lovászi¹, Szilárd Póliska³

¹Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Experimental Dermatology

|October 18, 2015

Summary

Sebocytes, skin cells, express adipokines, inflammatory proteins similar to fat cells. This suggests sebocytes play a key role in skin inflammation, not just as targets but as initiators.

Keywords:

adipokine inflammation sebocyte

More Related Videos

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Related Experiment Videos

Last Updated: Mar 31, 2026

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Area of Science:

Dermatology
Cell Biology
Immunology

Background:

Sebocytes, skin cells, share similarities with adipocytes, linking lipid metabolism and inflammation.
Adipocyte-derived inflammatory proteins (adipokines) have not been previously characterized in sebocytes.

Purpose of the Study:

To identify and characterize adipokines in human sebaceous glands and sebocyte cell lines.
To investigate the role of sebocytes in skin inflammatory processes through adipokine expression.

Main Methods:

Analysis of adipokine expression in healthy and diseased skin samples (acne, rosacea, melanoma, psoriasis).
Characterization of adipokine expression and secretion in SZ95 sebaceous gland cell line under various stimuli (TLR agonists, 13-cis retinoic acid).

Main Results:

Sebaceous glands consistently expressed adiponectin, IL6, resistin, leptin, serpin E1, and visfatin.
Apelin, chemerin, RBP4, and MCP1 were not detected in sebaceous glands.
Expression of most detected adipokines correlated with secreted protein levels and could be regulated at the gene expression level.

Conclusions:

Sebocytes express and secrete adipokines, supporting their similarity to adipocytes.
Sebocytes may initiate and modulate skin inflammatory responses through adipokine expression and secretion.