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ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH HYPOTHYROIDISM AND CONCOMITANT CHRONIC CHOLECYSTITIS

I Prysyazhnyuk1, N Pashkovska1

  • 1Bukovinian State Medical University, Chernivtsi, Ukraine.

Georgian Medical News
|October 21, 2015
PubMed

Insights

Hypothyroidism and chronic cholecystitis patients show increased endothelial dysfunction markers. Bilirubin may protect against this dysfunction, suggesting a potential therapeutic target for vascular health.

Area of Science:

  • Endocrinology
  • Hepatology
  • Vascular Biology

Background:

  • Endothelial dysfunction is a key factor in cardiovascular disease.
  • Hypothyroidism and chronic cholecystitis are common conditions with potential systemic effects.
  • The interplay between these conditions and endothelial health requires further investigation.

Purpose of the Study:

  • To investigate endothelial dysfunction markers in patients with hypothyroidism and chronic cholecystitis.
  • To explore the relationship between cholestasis, vascular endothelium growth factor (VEGF), endotheliocytes, and bilirubin levels in these patients.

Main Methods:

  • Assessed activity of lactate dehydrogenase and alkaline phosphatase.
  • Measured plasma levels of vascular endothelium growth factor (VEGF).
  • Quantified the number of circulating endotheliocytes and bilirubin levels.

Main Results:

  • Patients exhibited elevated lactate dehydrogenase and alkaline phosphatase, indicating cholestasis.
  • Increased plasma VEGF and endotheliocyte counts were observed, suggesting accelerated endothelial dysfunction.
  • An inverse correlation was found between VEGF, endotheliocytes, and bilirubin levels.

Conclusions:

  • Concomitant hypothyroidism and chronic cholecystitis accelerate endothelial dysfunction.
  • Bilirubin may play a protective role in mitigating endothelial dysfunction in these patients.
  • Further research into bilirubin's role could inform therapeutic strategies for vascular health.

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