[INTERRELATIONS BETWEEN MICROALBUMINURIA AND RENAL FUNCTION WITH CONTRACTILE ABILITY OF LEFT VENTRICLE IN CARDIORENAL...

Area of Science:

• Nephrology
• Cardiology
• Internal Medicine

Background:

• Chronic kidney disease (CKD) elevates mortality and cardiovascular risks.
• Cardiorenal syndrome (CRS) describes the interplay between heart and kidney diseases.
• Understanding the relationship between renal dysfunction and cardiac changes is crucial.

Purpose of the Study:

• To investigate the interrelations between left ventricular remodeling, microalbuminuria (MA), and renal dysfunction in CRS patients.
• To identify specific levels of MA associated with cardiac functional changes.

Main Methods:

• Echocardiography assessed left ventricular (LV) function and remodeling.
• Microalbuminuria (MA) was measured using diagnostic strips.
• Glomerular filtration rate (GFR) was estimated using the Cockcroft-Gault method.

Main Results:

• A significant association was found between MA and decreased GFR and elevated creatinine.
• Increased LV myocardial mass and preclinical LV systolic dysfunction correlated with MA.
• A direct correlation existed between MA and myocardial mass index, and an indirect correlation with LV ejection fraction.

Conclusions:

• MA levels around 25.4±5.8 ng/ml indicate a higher probability of LV contractile functional changes.
• Early prediction and prevention of CRS progression are possible through monitoring MA.
• This data supports pathogenetically approved pharmacotherapy for CRS patients.