Related Experiment Video

Updated: Mar 31, 2026

A Multiplex Serological Assay for the Detection of Antibody Responses to Arboviruses
05:22

A Multiplex Serological Assay for the Detection of Antibody Responses to Arboviruses

Published on: November 4, 2025

798

EPIDEMIOLOGY, CLINICAL AND LABORATORY FEATURES OF CRIMEAN-CONGO HEMORRHAGIC FEVER IN GEORGIA

E Vashakidze1, I Mikadze1

  • 1Tbilisi State Medical University, Department of Infectious Disease, Georgia.

Georgian Medical News
|October 21, 2015
PubMed

Insights

Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne illness. Predictors of fatality include altered mental status, low platelet counts, high liver enzymes, and prolonged clotting times.

Area of Science:

  • Medical Entomology
  • Infectious Diseases
  • Epidemiology

Background:

  • Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted by Hyalomma ticks and contact with infected blood.
  • CCHF presents with fever, rash, and bleeding, and has a high fatality rate (15-85%).

Purpose of the Study:

  • To identify predictors of fatality in Crimean-Congo hemorrhagic fever patients.
  • Analyze epidemiological, clinical, and laboratory findings associated with CCHF outcomes.

Main Methods:

  • Retrospective study of 34 CCHF patients (ages 4-77) in Shua Kartli, Georgia.
  • Data collected on demographics, exposure history (tick bites, livestock contact), clinical signs, and laboratory results.

Main Results:

  • Fatal cases (3/34) were associated with farming/livestock handling and tick bites.
  • Key clinical features include acute onset, high fever, intoxication, hemorrhagic symptoms, thrombocytopenia, elevated aminotransferases, and creatine.
  • Fatality predictors identified: altered mental status, severe thrombocytopenia, high aspartate aminotransferase, prolonged prothrombin time, and elevated INR.

Conclusions:

  • Farming and tick exposure are significant risk factors in the studied region.
  • Early identification of altered mental status, severe thrombocytopenia, and elevated liver enzymes can predict CCHF fatality.

More Related Videos

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

17.8K
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.3K

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
24
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
48
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
25
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
96
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
54
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
794