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Distant Recurrence Risk after Late Ipsilateral Breast Tumor Recurrence: Results of a Retrospective,
Makoto Ishitobi1, Jun Okuno, Nobuyoshi Kittaka
1Department of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Objectives:
There is limited information regarding risk factors for distant recurrence in patients with late ipsilateral breast tumor recurrence (IBTR).
Methods:
Late IBTR was defined as IBTR occurring >5 years after the initial surgery. Seventy-eight patients with late IBTR were reviewed to examine the risk factors of distant recurrence.
Results:
The negative estrogen receptor and positive HER2 statuses of IBTR were significantly correlated with poorer distant disease-free survival (p=0.03 and 0.02, respectively). Multivariate analyses demonstrated that the HER2 status of IBTR was an independent predictive factor of distant recurrence (p=0.04).
Conclusions:
The results of our retrospective, single-institution study revealed that the HER2 status of IBTR was an independent predictive factor of distant recurrence in patients with late IBTR.
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