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THE NEUROLOGICAL FACE OF CELIAC DISEASE
1Department of Pediatric Neurology, Faculty of Medicine, Sutcu Imam University, Kahramanmaras, Turkey, BR.
Insights
Neurological disorders are common in children with celiac disease, affecting 13.5% at diagnosis. Celiac disease management should consider these neurological manifestations.
Area of Science:
- Pediatric Neurology
- Gastroenterology
- Celiac Disease Research
Background:
- Celiac disease is increasingly associated with various neurological disorders.
- Understanding the spectrum of these neurological manifestations is crucial for comprehensive patient care.
Purpose of the Study:
- To determine the incidence of neurological manifestations in children diagnosed with celiac disease.
- To review and discuss these findings in the context of current medical literature.
Main Methods:
- A prospective cross-sectional study was conducted.
- Medical records of 297 children newly diagnosed with celiac disease were analyzed.
Main Results:
- 13.5% (40 out of 297) of celiac patients exhibited neurological findings.
- Common manifestations included headache, epilepsy, migraine, and attention deficit hyperactivity disorder.
- Biopsy type 3b was significantly more prevalent in patients with neurological symptoms, unlike type 3a.
Conclusions:
- Neurological manifestations are a notable feature in the clinical presentation of childhood celiac disease.
- Clinicians should be vigilant for these neurological signs during the diagnosis and management of celiac disease.
Background:
Several neurological disorders have also been widely described in celiac disease patients.
Objective:
The aim of this study was to determine the incidence of accompanying different neurologic manifestations in children with celiac disease at the time of diagnosis and to discuss these manifestations in the light of the recent literature.
Methods:
This prospective cross sectional study included 297 children diagnosed with celiac disease. The medical records of all patients were reviewed.
Results:
In neurological evaluation, totally 40 (13. 5%) of the 297 celiac patients had a neurological finding including headache, epilepsy, migraine, mental retardation, breath holding spells, ataxia, cerebral palsy, attention deficit hyperactivity disorder, Down syndrome and Turner syndrome in order of frequency. There was not any significant difference between the laboratory data of the patients with and without neurological manifestations. However; type 3a biopsy was statistically significantly more common among patients without neurological manifestations, while type 3b biopsy was statistically significantly more common among patients with neurological manifestations.
Conclusion:
It is important to keep in mind that in clinical course of celiac disease different neurological manifestations may be reported.
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