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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

The Human Endometrium-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling.

Agata Zieba¹, Evelina Sjöstedt², Matts Olovsson³

¹1 Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University , Uppsala, Sweden .

Omics : a Journal of Integrative Biology

|October 22, 2015

Summary

This summary is machine-generated.

Researchers identified 101 genes with higher expression in the human endometrium using transcriptomics and protein profiling. This study enhances understanding of female reproductive biology and related diseases.

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Area of Science:

Reproductive Biology
Genomics
Proteomics

Background:

The human endometrium undergoes dynamic, hormone-dependent changes in fertile females.
Understanding endometrial gene expression is crucial for reproductive health.

Purpose of the Study:

To identify genes with elevated expression in the normal human endometrium.
To analyze gene and protein expression patterns at a cellular level.

Main Methods:

Genome-wide transcriptomics (RNA-Seq) on human endometrial tissues.
Immunohistochemistry-based protein profiling.
Comparison of endometrial expression data with 31 RNA and 44 protein tissue types.

Main Results:

Identified 101 genes with elevated expression in the endometrium.
Four genes showed more than five-fold higher expression in the endometrium compared to other tissues.
Localized protein expression at a cellular resolution.

Conclusions:

Comprehensive lists of genes with elevated endometrial expression were generated.
Provides a foundation for understanding human reproductive biology.
Offers insights into endometrial diseases.