Comparison between procalcitonin, brain natriuretic peptide, and uric acid in children with cardiomyopathy and controls
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Published on: April 29, 2013
Noor Mohammad Noori1, Maziar Mahjoubifard1, Iraj Shahramian2
1Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran.
Insights
Biomarkers Brain Natriuretic Peptide (BNP), procalcitonin, and uric acid were elevated in children with cardiomyopathy. BNP levels correlated with illness severity, unlike procalcitonin and uric acid.
Area of Science:
- Biochemistry
- Pediatric Cardiology
- Medical Diagnostics
Background:
- Cardiomyopathy in children presents diagnostic challenges.
- Identifying reliable biomarkers is crucial for assessing disease severity and progression.
Purpose of the Study:
- To compare levels of procalcitonin, Brain Natriuretic Peptide (BNP), and uric acid in children with cardiomyopathy versus controls.
- To investigate the association between these biomarkers and echocardiographic findings in pediatric cardiomyopathy.
Main Methods:
- Serum levels of BNP, procalcitonin, and uric acid were measured in pediatric patients with cardiomyopathy and healthy controls.
- Biomarker levels were statistically compared between groups and correlated with echocardiographic parameters.
Main Results:
- Children with cardiomyopathy exhibited significantly higher mean levels of BNP, procalcitonin, and uric acid compared to controls (p<0.001).
- Echocardiographic indices showed significant differences between cases and controls (p<0.05).
- In patients, Brain Natriuretic Peptide (BNP) correlated with the Ross classification of disease severity (p<0.05) and age (p<0.05), while procalcitonin and uric acid did not show significant correlations.
Conclusions:
- Procalcitonin, uric acid, and BNP are significantly associated with echocardiographic findings in pediatric cardiomyopathy.
- While procalcitonin and uric acid did not correlate with disease severity in this cohort, BNP levels effectively indicated illness severity based on the Ross classification and age.
Objective:
This study was performed to determine the level of procalcitonin, Brain Natriuretic Peptide (BNP), and uric acid in children with cardiomyopathy in comparison with controls and the association with echocardiographic findings.
Methods:
The levels of BNP, procalcitonin, and serum uric acid were measured and the amounts of biomarkers compared with echocardiographic findings.
Results:
In this study mean age of participants was the same (p=0.321). The majority of echocardiographic indices in left and right heart have different means in case and controls (p<0.05). Means of BNP, procalcitonin, and uric acid were 213.814 ± 309.601, 9.326 ± 3.881, and 6.846 ± 1.814 for case group and 2.76 ± 1.013, 1.851 ± 1.466, and 3.317 ± 0.924 for control (p<0.001), respectively. In the patients group there was relationship of Ross classification with BNP (χ (2) = 15.845, p<0.05) and with age (χ (2) = 8.946, p<0.05). For uric acid and procalcitonin no significant relationships were observed.
Conclusions:
Procalcitonin, uric acid, and BNP had significant relationship with many echocardiographic findings in participants. For patients, procalcitonin did not show correlation. The severity of illness based on the Ross classification showed significant correlation with BNP level and age in patients.
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