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Updated: Mar 31, 2026
Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier
Published on: November 12, 2013
Platelets Contribute to BBB Disruption Induced by HIV and Alcohol
Madhavan Nair1, Jose Mb Maria2, Marisela Agudelo3
1Professor and Chair, Institute of Neuro-Immune Pharmacology, Department of Immunology, Florida International University, Miami, FL, USA.
Abstract:
The role of platelets in the neurological diseases that underlie cognitive impairment has attracted increasing attention in recent years. Multiple pathways in platelets contribute to host defenses, as well as to CNS function. In the current study, we hypothesize that the Blood Brain Barrier (BBB) is disrupted when exposed to platelets from patients with triple Co-morbidity (hazardous alcohol users+ HIV+ thrombocytopenia), compared to those with dual, single or no morbidity (HIV only, alcohol only or healthy controls).
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