Related Experiment Video
Updated: Mar 31, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
BEND3 mediates transcriptional repression and heterochromatin organization
Abid Khan1, Supriya G Prasanth1
1a Department of Cell and Developmental Biology ; University of Illinois at Urbana-Champaign ; Urbana , IL USA.
Abstract:
Transcription repression plays a central role in gene regulation. Transcription repressors utilize diverse strategies to mediate transcriptional repression. We have recently demonstrated that BEND3 (BANP, E5R and Nac1 domain) protein represses rDNA transcription by stabilizing a NoRC component. We discuss the role of BEND3 as a global regulator of gene expression and propose a model whereby BEND3 associates with chromatin remodeling complexes to modulate gene expression and heterochromatin organization.
Related Concept Videos
RNA Polymerase II Accessory Proteins
Co-activators and Co-repressors
Co-activators and Co-repressors
Heterochromatin
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
Heterochromatin
Spreading of Chromatin Modifications
Writers
The writer...

