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Neurologic Complications Caused by Epstein-Barr Virus in Pediatric Patients

Katarzyna Mazur-Melewska1, Iwona Breńska2, Katarzyna Jończyk-Potoczna3

  • 1Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland katarzynam-m@wp.pl.

Journal of Child Neurology
|October 30, 2015
PubMed

Insights

Epstein-Barr virus (EBV) commonly affects children, causing neurological issues like febrile seizures and severe complications such as meningoencephalitis. Routine EBV testing is recommended for pediatric neuroinfections.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neurology

Background:

  • Epstein-Barr virus (EBV) is a common viral infection in children.
  • Neurological complications associated with EBV can be diverse and severe.

Purpose of the Study:

  • To analyze the incidence and spectrum of EBV infections in children.
  • To identify EBV-associated neurological complications in pediatric patients.

Main Methods:

  • Retrospective analysis of medical records from 194 children with EBV infection.
  • Diagnosis confirmed by clinical symptoms and viral capsid antigen IgM antibody.
  • Neurological examination, MRI, and EEG for patients with severe complications.

Main Results:

  • Two incidence peaks observed: 1-5 years (62.0%) and teenagers (24.6%).
  • Febrile seizures occurred in 3.1% of young children; headaches in 24.2% of older children.
  • Ten children experienced severe neurological complications including meningoencephalitis and transverse myelitis.

Conclusions:

  • EBV is a significant cause of pediatric neuroinfections.
  • EBV can manifest with a wide range of neurological symptoms and complications.
  • Routine EBV testing is advised for children presenting with neuroinfection symptoms.

Keywords:
Epstein-Barr viruscerebellitischildrenencephalitisinfectious mononucleosismyeloradiculitis

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