Related Experiment Video
Updated: Mar 31, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Resistin and Insulin Resistance: A Link Between Inflammation and Hepatocarcinogenesis
Engy Yousry Elsayed1, Nesreen Ahmed Mosalam, Noha Refaat Mohamed
1Internal Medicine, Oncology and Clinical Pathology Departments, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Background:
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer related death overall. The role of insulin resistance in the development of HCC associated with chronic HCV infection has not been established. Resistin is a polypeptide hormone belonging to the adipokine family which could contribute to tumorigenesis and angiogenesis. Our aim was to study serum resistin and insulin resistance as risk factors for HCC in HCV cirrhotic patients.
Materials And Methods:
This prospective case controlled study included 100 patients with HCV related liver cirrhosis and HCC, 100 patients with HCV related liver cirrhosis without HCC and 50 apparently healthy participants as controls. For all subjects, liver profile, serologic markers for viral hepatitis, lipid profile, alpha-fetoprotein level (AFP), homeostasis model assessment (HOMA) were examined along with resistin.
Results:
HCC patients had higher mean values of HOMA-IR and resistin than cirrhotic patients and the control subjects (p<0.01). HOMA and resistin were considered independent risk factors in development of HCC, those patients with resistin > 12 ng/ml and HOMA >4 being 1.6 times more likely to have HCC.
Conclusions:
HOMA and serum resistin allow for early identification of patients with cirrhosis who are at substantially increased risk of HCC.
Recommendation:
HOMA and serum resistin could represent novel markers to identify HCV cirrhotic patients at greater risk of development of HCC.
More Related Videos
08:32Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
Related Concept Videos
Insulin: The Receptor and Signaling Pathways
PI3K/mTOR/AKT Signaling Pathway
Regulation of the Unfolded Protein Response
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
Psychoneuroimmunology: Diabetes and Cancer
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal