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Related Experiment Video

Updated: Mar 31, 2026

A Low Cost Setup for Behavioral Audiometry in Rodents

A Low Cost Setup for Behavioral Audiometry in Rodents

Published on: October 16, 2012

Animal models of tinnitus.

Thomas J Brozoski¹, Carol A Bauer¹

¹Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Hearing Research

|November 2, 2015

Summary

Animal models are crucial for understanding tinnitus, a complex auditory sensation often linked to hearing loss. New research suggests therapies may focus on attention to tinnitus rather than the sound itself.

Area of Science:

Neuroscience
Auditory Science
Animal Models

Background:

Chronic tinnitus is a persistent, subjective sound sensation often following hearing loss.
Tinnitus involves complex central nervous system substrates beyond classically auditory areas.
Animal models have been instrumental in understanding tinnitus neurophysiology for over 27 years.

Purpose of the Study:

To review animal models of tinnitus from a functional perspective.
To categorize existing animal models and discuss their strengths and limitations.
To explore the potential of animal models in understanding cognitive aspects of tinnitus.

Main Methods:

Categorization of animal models into 'interrogative' (behavior-dependent) and 'reflexive' (reflex modulation) types.

Keywords:

Animal model Future directions Thematic review Tinnitus

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Last Updated: Mar 31, 2026

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Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

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Review of models originating from Jastreboff's 1988 experiments, noting common features.

Discussion of sound-gap modulation of the acoustic startle response as a reflexive model.

Main Results:

Diverse animal models exist, but none is a clear standard; all share common features.
Interrogative models require training and reflect tinnitus perception; reflexive models use involuntary responses.
A new model shows tinnitus interacts with auditory attention, suggesting attention modification as a therapeutic target.

Conclusions:

Animal models have significantly advanced tinnitus neuroscience, primarily focusing on sensory features.
While emotional aspects of tinnitus are difficult to model, cognitive factors are increasingly accessible.
Therapeutic strategies for tinnitus may benefit from targeting attentional mechanisms rather than the sensation directly.