[Clinical Features and Pathogenic Mechanisms of Parkinson Disease With Pure Apathy]

Parkinson disease (PD) is a common neurodegenerative disease characterized by classical motor symptoms, including static tremor, bradykinesia, rigidity and postural and gait abnormalities. Besides, recent studies have found a variety of non-motor symptoms, including neuropsychiatric symptoms, sleep disorders, abnormal sensory and autonomic dysfunctions, etc. PD with pure apathy, referring to apathy without dementia and depression, is correlated with motor symptoms and other non-motor symptoms, and greatly reduces the activity of daily living and the quality of life for PD patients. The pathogenesis of PD with pure apathy involves the mechanisms of neuroanatomy, neuropathology, neurological biochemistry and neuroinflammation. This paper will introduce the clinical features and pathogenic mechanisms of PD with pure apathy.