Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Translational Regulation01:29

Translational Regulation

810
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
810
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Leaky Scanning02:28

Leaky Scanning

5.9K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.9K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

77
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
77
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

13.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
13.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photoallergic erythroderma due to doxycycline therapy of erythema chronicum migrans.

Acta dermato-venereologica·2011
Same author

Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis.

Journal of immunology (Baltimore, Md. : 1950)·2010
Same author

Effect of calcipotriol on etanercept partial responder psoriasis vulgaris and psoriatic arthritis patients.

Acta dermato-venereologica·2009
Same author

Photodynamic therapy for granuloma annulare: more than a shot in the dark.

Dermatology (Basel, Switzerland)·2008
Same author

Detection of the 47-kilodalton membrane immunogen gene of Treponema pallidum in various tissue sources of patients with syphilis.

Diagnostic microbiology and infectious disease·2005
Same journal

GRAPPA 2019 Research Recipient Awards Report.

The Journal of rheumatology. Supplement·2021
Same journal

GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting.

The Journal of rheumatology. Supplement·2021
Same journal

GRAPPA Patient Research Partner Network: Update to the GRAPPA 2020 Annual Meeting.

The Journal of rheumatology. Supplement·2021
Same journal

Instruments Measuring Physical Function for Psoriatic Arthritis Endorsed at GRAPPA 2020 Annual Meeting: Updates of the GRAPPA-OMERACT Working Group.

The Journal of rheumatology. Supplement·2021
Same journal

GRAPPA 2020 Update From the Education Committee.

The Journal of rheumatology. Supplement·2021
Same journal

The Role of Ultrasound in Research and Clinical Practice in Psoriatic Arthritis: Highlights From the GRAPPA Ultrasound Workshop.

The Journal of rheumatology. Supplement·2021
See all related articles

Related Experiment Video

Updated: Mar 30, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.0K

Translational Research in Psoriasis.

Joerg Christoph Prinz1

  • 1From the Department of Dermatology, Ludwig-Maximilian University of Munich, Munich, Germany.J.C. Prinz, Assistant Medical Director, Professor. joerg.prinz@med.uni-muenchen.de.

The Journal of Rheumatology. Supplement
|November 3, 2015
PubMed
Summary
This summary is machine-generated.

Translational research converts basic science into new psoriasis treatments. This process has led to effective and safe therapies, improving public health outcomes.

Keywords:
ETIOLOGYPSORIASISTHERAPYTRANSLATIONAL RESEARCH

More Related Videos

Polysome Profiling in Leishmania, Human Cells and Mouse Testis
14:32

Polysome Profiling in Leishmania, Human Cells and Mouse Testis

Published on: April 8, 2018

19.0K
SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
06:34

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

Published on: August 8, 2025

666

Related Experiment Videos

Last Updated: Mar 30, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.0K
Polysome Profiling in Leishmania, Human Cells and Mouse Testis
14:32

Polysome Profiling in Leishmania, Human Cells and Mouse Testis

Published on: April 8, 2018

19.0K
SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
06:34

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

Published on: August 8, 2025

666

Area of Science:

  • Biomedical research
  • Translational science
  • Dermatology

Background:

  • Psoriasis pathogenesis insights have driven therapeutic development.
  • Genetic predisposition and pathogenetic events highlight the cytokine cascade.
  • Cytokine pathways are key targets for novel psoriasis interventions.

Purpose of the Study:

  • To highlight the role of translational research in developing new psoriasis therapies.
  • To demonstrate how basic science advances inform clinical applications.
  • To emphasize the public health impact of effective psoriasis treatments.

Main Methods:

  • Utilizing insights from basic science and disease pathogenesis.
  • Integrating genetic and pathogenetic data.
  • Applying phased translational research methodologies.

Main Results:

  • Development of novel therapeutic approaches for psoriasis.
  • New therapies exhibit high efficacy.
  • New therapies demonstrate convincing safety profiles.

Conclusions:

  • Translational research effectively translates scientific discoveries into clinical practice.
  • Targeting the cytokine cascade has yielded successful psoriasis treatments.
  • These advancements have significant positive implications for public health.