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What Do Very Low Plasma Concentrations of High-sensitivity C-reactive Protein (hs-CRP) Mean among Healthy Middle-aged
Min-Gul Kim1, Baik-Hwan Cho2, Soo-Wan Chae3
1Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
Insights
Even within low-risk groups, higher high-sensitivity C-reactive protein (hs-CRP) levels correlate with central obesity. Lowering hs-CRP through lifestyle changes is recommended for public health, viewing it as a wellness indicator.
Area of Science:
- Biomedical Science
- Cardiovascular Health
- Inflammation Research
Background:
- Systemic low-grade inflammation (SLGI), indicated by high-sensitivity C-reactive protein (hs-CRP), is a significant cardiovascular disease (CVD) risk factor.
- Current guidelines classify individuals with hs-CRP ≤ 1 mg/L as low risk, but the implications of very low levels (<0.5 mg/L) remain unclear.
Purpose of the Study:
- To investigate the association between very low hs-CRP levels and cardiovascular risk factors in healthy adults.
- To evaluate the clinical significance of hs-CRP concentrations below 1 mg/L for public health practices.
Main Methods:
- Cross-sectional cohort study of 104 healthy Korean adults (aged 34-60 years).
- Assessment included anthropometric measurements, computed tomography, bioelectrical impedance analysis, and fasting blood biomarkers.
- hs-CRP levels were analyzed, with a focus on subgroups below 1 mg/L.
Main Results:
- 84.6% of subjects had hs-CRP ≤ 1.0 mg/L.
- Individuals with hs-CRP <0.5 mg/L exhibited superior anthropometric profiles regarding central obesity and lipid levels compared to those with hs-CRP between 0.5 and 1 mg/L.
- Higher hs-CRP within the low-risk group (<1 mg/L) was linked to increased central obesity.
Conclusions:
- Even in individuals classified as low risk for CVD, elevated hs-CRP levels may indicate increased central obesity.
- Lifestyle modifications aimed at reducing hs-CRP should be promoted in public health initiatives.
- hs-CRP should be considered a marker of wellness rather than solely a risk marker.
Background:
Systemic low-grade inflammation (SLGI), as assessed by measurements of high-sensitivity C-reactive protein (hs-CRP), is a strong independent risk factor for cardiovascular diseases (CVD). Although individuals with hs-CRP ≤ 1 mg/L have been defined as being at low risk according to AHA/CDC guidelines, the value of very low hs-CRP levels (<0.5 mg/L) for public health practices is unclear.
Methods:
This cross-sectional cohort study assessed 104 healthy Koreans aged 34-60 years. Their anthropometric indices, results of computed tomography and bioelectrical impedance analysis, and biomarker concentrations in fasting venous blood samples were evaluated.
Results:
Of 104 subjects, 88 (84.6%) had hs-CRP concentrations ≤ 1.0 mg/L. When this low risk group was subdivided into subjects with hs-CRP <0.5 mg/L and hs-CRP levels between 0.5 and 1 mg/L, the former group showed better anthropometric profiles for central obesity and lipidemia.
Conclusion:
Even in low risk subjects, higher serum concentrations of hs-CRP may be associated with increased central obesity. Lifestyle modifications to lower hs-CRP should be recommended in public health practice, with hs-CRP viewed not as a risk marker, but rather as a marker of wellness.
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