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Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

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Microarray Analysis Gene Expression Profiles in Laryngeal Muscle After Recurrent Laryngeal Nerve Injury.

Khadijeh Bijangi-Vishehsaraei¹, Kevin Blum², Hongji Zhang¹

¹Department of Pharmacology and Toxicology, Indiana University, Indianapolis, Indiana, USA.

The Annals of Otology, Rhinology, and Laryngology

|November 5, 2015

Summary

This summary is machine-generated.

Recurrent laryngeal nerve (RLN) injury shows distinct gene expression in laryngeal muscles. The adductor complex (AC) indicates reinnervation, while the posterior cricoarytenoid (PCA) muscle shows degeneration, suggesting different recovery pathways.

Keywords:

denervation laryngeal muscles larynx recurrent laryngeal nerve vocal fold

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Author Spotlight: Regenerative Roles of Muscle Proteins at Neuromuscular Junction Post-Nerve Injury

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Area of Science:

Neuroscience
Molecular Biology
Regenerative Medicine

Background:

Recurrent laryngeal nerve (RLN) injury typically results in significant spontaneous reinnervation.
Laryngeal adductor complex (AC) reinnervation often precedes that of the posterior cricoarytenoid (PCA) muscle.
The underlying molecular mechanisms driving differential reinnervation remain unclear.

Purpose of the Study:

To investigate the differential gene expression in laryngeal muscles following RLN injury.
To identify myogenic factors potentially responsible for the observed spontaneous reinnervation patterns.

Main Methods:

F344 male rats underwent either RLN transection (n=12) or sham surgery (n=12).
Larynges were harvested one week post-injury for mRNA extraction from bilateral AC and PCA muscles.
Microarray analysis using a full rat genome array was performed on the extracted mRNA.

Main Results:

Microarray analysis revealed significant differences in gene expression profiles between denervated AC and PCA muscles.
205 individual probes showed differential expression between the two muscle groups.
Only 14 genes exhibited similar expression patterns across both muscles.

Conclusions:

Differential gene expression in AC and PCA muscles suggests distinct reinnervation mechanisms.
PCA muscles displayed gene patterns consistent with Wallerian degeneration.
AC muscles showed gene patterns indicative of reinnervation via adjacent axonal sprouting, highlighting potential therapeutic targets for nerve injury.