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Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position

Sandeep Gawaskar1, Dirk Schepmann2, Alessandro Bonifazi3

  • 1Institut für Pharmazeutische und Medizinische Chemie der Universität Münster, Corrensstraße 48, 48149 Münster, Germany; NRW Graduate School of Chemistry, Wilhelm-Klemm-Straße 10, 48149 Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), Westfälische Wilhelms-Universität Münster, Germany.

Bioorganic & Medicinal Chemistry Letters
|November 5, 2015
PubMed

Keywords:
2-Nitrobenzo[7]annulen-7-aminesConformational restrictionDocking studiesGluN2B antagonistsNMDA receptorSelectivityStructure affinity relationships

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