Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

844
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
844
Drug Product Stability01:16

Drug Product Stability

348
The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
348
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

666
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
666
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

216
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
216
Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

6.0K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
6.0K
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

1.6K
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel liquid-based approaches for transmucosal drug delivery.

Acta pharmaceutica Sinica. B·2026
Same author

Differentiating Resistance from Formulation Failure: Isoniazid Instability and Poor Dissolution in Crushed Multi-Drug Paediatric Preparations.

Pharmaceutics·2026
Same author

Protein-based nanoparticles in the treatment of respiratory infectious diseases: current progress and future directions.

Nanomedicine (London, England)·2026
Same author

Malaria: a review on its current epidemiological status and management strategies.

Malaria journal·2026
Same author

Therapeutic and Formulation Advances of Ivermectin in Veterinary and Human Medicine.

Pharmaceutics·2025
Same author

From Liquid SNEDDS to Solid SNEDDS: A Comprehensive Review of Their Development and Pharmaceutical Applications.

The AAPS journal·2025

Related Experiment Video

Updated: Mar 30, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.7K

Amorphous Sulfadoxine: A Physical Stability and Crystallization Kinetics Study.

Marique Aucamp1, Marnus Milne2, Wilna Liebenberg2

  • 1Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, Potchefstroom Campus, North-West University, 2520, Potchefstroom, South Africa. marique.aucamp@nwu.ac.za.

AAPS Pharmscitech
|November 5, 2015
PubMed
Summary

This study prepared amorphous sulfadoxine, a metastable drug form, to improve solubility. While stable, amorphous sulfadoxine

Keywords:
amorphouscrystallization kineticsstabilitysulfadoxine

More Related Videos

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
06:18

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate

Published on: April 24, 2018

8.9K
PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase
09:31

PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase

Published on: September 26, 2020

4.9K

Related Experiment Videos

Last Updated: Mar 30, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.7K
Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
06:18

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate

Published on: April 24, 2018

8.9K
PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase
09:31

PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase

Published on: September 26, 2020

4.9K

Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry

Background:

  • Poor aqueous solubility is a persistent challenge in drug formulation.
  • Metastable solid-state forms can enhance drug solubility and therapeutic efficacy.
  • Sulfadoxine-pyrimethamine remains crucial for treating Plasmodium falciparum malaria.

Purpose of the Study:

  • To prepare an amorphous form of sulfadoxine.
  • To investigate the physical stability and recrystallization kinetics of amorphous sulfadoxine.
  • To assess the potential of amorphous sulfadoxine for improved drug delivery.

Main Methods:

  • Amorphous sulfadoxine prepared via melt quench cooling.
  • Characterization using hot-stage microscopy (HSM), SEM, XRPD, DSC, TGA, and microcalorimetry.
  • Recrystallization kinetics analyzed using Johnson-Mehl-Avrami and Kissinger models.

Main Results:

  • Sulfadoxine identified as a good glass former with notable physical stability.
  • Water identified as a plasticizer, negatively impacting amorphous sulfadoxine stability under humid conditions.
  • Polyvinylpyrrolidone-25 (PVP-25) investigated for physical stabilization.

Conclusions:

  • Amorphous sulfadoxine offers potential for enhanced solubility and malaria treatment.
  • Careful control of moisture is essential for maintaining the stability of amorphous sulfadoxine formulations.
  • Further research into stabilization strategies is warranted for practical pharmaceutical applications.