SERPINE1 rs1799768 polymorphism contributes to sepsis risk and mortality
Qiankun Shi1, Xinwei Mu1, Liang Hong1
1Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, China.
Journal of the Renin-Angiotensin-Aldosterone System : JRAAS
|November 6, 2015
Summary
Genetic variations in SERPINE1 rs1799768 are linked to increased sepsis risk and mortality. This polymorphism affects sepsis outcomes in both Asian and Caucasian populations.
Area of Science:
- Genetics
- Molecular Biology
- Critical Care Medicine
Background:
- Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Genetic factors play a role in sepsis susceptibility and outcomes.
- The SERPINE1 rs1799768 polymorphism is a candidate genetic marker for sepsis.
Purpose of the Study:
- To conduct a meta-analysis investigating the association between the SERPINE1 rs1799768 polymorphism and sepsis risk.
- To evaluate the association between the SERPINE1 rs1799768 polymorphism and sepsis-related mortality.
- To explore ethnic differences in these associations.
Main Methods:
- A systematic literature search was performed across major scientific databases (PubMed, PubMed Central, Gene, PubChem, Google Scholar).
- Data extraction and synthesis were conducted using a random-effects model to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
- Subgroup analyses were performed based on ethnicity.
Main Results:
- The meta-analysis revealed a significant association between the SERPINE1 rs1799768 polymorphism and increased sepsis risk (OR = 1.30; p = 0.006).
- A significant association was also found between this polymorphism and increased sepsis mortality risk (OR = 1.73; p < 0.0001).
- Stratified analyses showed significant associations in both Asian and Caucasian populations for both sepsis risk and mortality.
Conclusions:
- The SERPINE1 rs1799768 polymorphism is significantly associated with an elevated risk of developing sepsis.
- This genetic polymorphism is also linked to a higher risk of sepsis-related mortality.
- The findings highlight the clinical relevance of SERPINE1 rs1799768 in sepsis pathogenesis and prognosis across diverse ethnic groups.
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